Acidosis in severe childhood malaria

Thrombocytopenia is predictive of lethality in severe childhood falciparum malaria.

Renal tubular acidosis in childhood

Increased knowledge on the genetics, the pathophysiology, the natural history and the treatment of renal tubular acidosis (RTA) has begun to clarify this often confusing field. To help pediatricians better acquainted with the physiological and genetic basis of the various types of RTA, to facilitate early diagnosis and treatment with the ultimate aim of preventing the significant growth failure...

Defining Childhood Severe Falciparum Malaria for Intervention Studies

BACKGROUND Clinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive, and appropriate for clinical purposes. However, this definition includes individuals with severe nonmalarial disease and coincident parasitaemia, so may lack specificity in vaccine trials. Although...

Severe Childhood Malaria Syndromes Defined by Plasma Proteome Profiles

BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood. Therefore it is important to understand the pathology underlying the development of CM and SMA, as opposed to uncomplicated malaria (UM). Different host responses to infection are likely to be reflected in plasma proteome-pat...

Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis.

BACKGROUND To date, information about the frequency of electrolyte disturbances among children with severe falciparum malaria is limited. METHODS We describe changes in potassium, calcium, magnesium, and phosphate levels in 56 Kenyan children (42 who survived and 14 who died) admitted to the hospital with clinical features of severe malaria (impaired consciousness or deep breathing) complicat...